Torque Teno Virus (SANBAN Isolate) ORF2 Protein Suppresses NF-κB Pathways via Interaction with IκB Kinases
نویسندگان
چکیده
منابع مشابه
Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65
Nuclear factor (NF)-κB is a master regulator of pro-inflammatory genes and is upregulated in human immunodeficiency virus 1 (HIV-1) infection. Mechanisms underlying the NF-κB deregulation by HIV-1 are relevant for immune dysfunction in AIDS. We report that in single round HIV-1 infection, or single-pulse PMA stimulation, the HIV-1 Tat transactivator activated NF-κB by hijacking the inhibitor Iκ...
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TTV has been recently identified as a causative agent of non-A to non-G hepatitis. However, the exact role of this virus in the pathogenesis of chronic liver disease (CLD) and the development of hepatocellular carcinoma (HCC) remain controversial. To clarify these issues, the prevalence of this virus and its impact on the severity of liver disease and development of HCC among Egyptian patients ...
متن کاملTorque teno virus: a ubiquitous virus
Torque teno virus (TTV) is a non-enveloped human DNA virus isolated by Nishizawa et al. in 1997.1 TTV, recently classified as the Alphatorquevirus genus within the Anelloviridae family by the International Committee on Taxonomy of Viruses (ICTV), was the first human virus with a single-stranded circular DNA genome to be identified.2 Thus far, five main genetic groups (Groups 1–5) involving at l...
متن کاملTorque teno virus: a ubiquitous virus☆
caid et al. showed that the TTV encodes a miRNA in vivo that orque teno virus (TTV) is a non-enveloped human DNA virus solated by Nishizawa et al. in 1997.1 TTV, recently classified s the Alphatorquevirus genus within the Anelloviridae family by he International Committee on Taxonomy of Viruses (ICTV), as the first human virus with a single-stranded circular DNA enome to be identified.2 Thus fa...
متن کاملA Fourth IκB Protein within the NF-κB Signaling Module
Soumen Basak, Hana Kim, Jeffrey D. Kearns, Vinay Tergaonkar, Ellen O’Dea, Shannon L. Werner, Chris A. Benedict, Carl F. Ware, Gourisankar Ghosh, Inder M. Verma, and Alexander Hoffmann* Department of Chemistry and Biochemistry Signaling Systems Laboratory University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA Laboratory of Genetics, Salk Institute for Biological Studies,...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2007
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.01101-07